Medical Marijuana May Be A Cure For Migraines, And Many Other Conditions

For the first time, researchers have completed a study that proves medical marijuana can treat migraines. A study like this has never been done before due to federal regulations preventing scientists in the U.S. from obtaining cannabis for research. Throughout the years, migraine and headache sufferers have turned to smoking pot to alleviate their pain, but this is the first time scientific evidence exists to back up their claims.

Researchers at the University of Colorado Anschutz Medical Campus gathered 121 participants who were diagnosed with migraines. They treated them with medical marijuana between January 2010 and September 2014, and found that their migraines were reduced from over 10 a month to less than five per month. The majority of participants — 103 of them — reported a decrease in migraines overall. And only three saw an increase in migraines over the course of the trial.

The trial participants used cannabis in different ways, too — either smoking or eating it. Inhaling marijuana was shown to be the most preferable way to treat headaches, since its effects occured sooner than those who used edibles.

The researchers call the results “significant,” and said they may potentially offer a way to jumpstart migraine treatments in states where medical marijuana is legal — or at least trigger more research. The list of states that have legalized medical marijuana is now up to 23, including California, Maryland, Massachusetts, New York, and Washington.

However, the researchers still remain cautious with how they present their results, noting that not everyone should turn to weed to cure their headaches. Marijuana affects everyone differently, and it can have negative effects on health, too.

“There was a substantial improvement for patients in their ability to function and feel better,” said Laura Borgelt, a professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences and an author of the study, in a press release. “Like any drug, marijuana has potential benefits and potential risks. It’s important for people to be aware that using medical marijuana can also have adverse effects.”

Regardless, the study is an addition to a growing body of scientific evidence that cannabis holds more potential power for health benefits than the “War on Drugs” would like to admit. Research has shown that cannabis may have benefits for people suffering from mental health disorders, like stress, anxiety, and post-traumatic stress disorder (PTSD). It has also been used to treat epilepsy, neurodegenerative diseases like Parkinson’s disease, and alleviate the painful side effects of cancer treatment. One recent study also found that smoking weed was linked to a 50 percent lower chance of developing metabolic syndrome and its symptoms, which include high blood sugar, high blood pressure, and high cholesterol. Some physicians are even clamoring for the right to use medical marijuana to treat glaucoma, an eye condition that may cause blindness.

More research will be needed to determine how exactly cannabis reduces migraines. “We believe serotonin plays a role in migraine headaches, but we are still working to discover the exact role of cannabinoids in this condition,” Borgelt said.

Source: Rhyne D, Anderson S, Gedde M, Borgelt L. Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population. Pharmacotherapy, 2016.

Study: THC can Prevent Inflammation Induced by Airway Diseases

A new study published in the journal Biochemical Pharmacology, and epublished ahead of print by the National Institute of Health, has found that THC – a compound found in cannabis – is beneficial in preventing inflammation caused by various airway diseases such as bronchitis and emphysema.

“Despite pharmacological treatment, bronchial hyperresponsiveness continues to deteriorate as airway remodelling persists in airway inflammation”, states researchers. “Previous studies have demonstrated that the phytocannabinoid Δ9-tetrahydrocannabinol (THC) reverses bronchoconstriction with an anti-inflammatory action. The aim of this study was to investigate the effects of THC on bronchial epithelial cell permeability after exposure to the pro-inflammatory cytokine, TNFα.”
For the study; “Calu-3 bronchial epithelial cells were cultured at air-liquid interface. Changes in epithelial permeability were measured using transepithelial electrical resistance (TEER), then confirmed with a paracellular permeability assay and expression of tight junction proteins by Western blotting.”
Researchers found that treatment with THC “prevented the TNFα-induced decrease in TEER and increase in paracellular permeability.”
The study concludes; “These data indicate that THC prevents cytokine-induced increase in airway epithelial permeability through CB2 receptor activation. This highlights that THC, or other cannabinoid receptor ligands, could be beneficial in the prevention of inflammation-induced changes in airway epithelial cell permeability, an important feature of airways diseases.”

Source: The Joint Blog

New potent derivative of cannabidiol could be key in the development of more effective cannabis-based medicine

A considerable number of human and animal studies indicate that Cannabidiol (CBD) exerts therapeutic effects in a wide range of health disorders. These include anxiety disorders, neuropathic pain, epilepsy, cancer treatment-related symptoms, and possibly schizophrenia, psychosis, depression and obsessive compulsive disorder.

Considering CBD’s general safety, it is somewhat surprising that it has not yet been marketed as a stand-alone drug (Sativex, which is available in Canada and some European countries, contains a 1:1 ration of THC and CBD). A reason for this might be due to its low potency, which requires that large doses be administered to achieve significant therapeutic effects. For instance, in human studies of anxiety, doses of 300 to 600 mg of CBD are needed to achieve effects comparable to those of 10 mg of diazepam (source).

In an attempt to overcome this hurdle, an international team of researchers from Israel and Brazil has been trying to create more potent molecules derived from CBD. The team focused on fluorination, a method employed by pharmacists worldwide to enhance endogenous and synthetic drugs, which is applied in nearly 20% of the new drugs released in the market. Using this method to add a fluorine atom to the “aromatic ring” of the CBD molecule, the researchers obtained a new and much more potent molecule (HUF-101). Their successful finding was published this July in the journal PLOS ONE.

After the chemical synthesis of HUF-101, different concentrations of the compound were tested in mice under four behavioral assays. These testrd for the presence of any protective effects against anxiety, depression, schizophrenia and compulsive behavior.

Overall, the experiment revealed strong protective effects of HUF-101 in the four assays. More importantly, when the data were compared to previous studies, it was obvious that similar effects to those of CBD were being achieved at much lower concentrations of HUF-101. In the anxiety and depression tests, comparable effects were observed at a tenth of the concentration; while in the schizophrenia and compulsive behavior tests, concentrations ranging from a twentieth to a third were holding the same effects.

In a subsequent manipulation, the researchers found that when they blocked CB1 or CB2 receptors, both CBD and the derivative HUF-101 lost their efficacy in preventing compulsive behavior. This suggests that an indirect activation of these receptors by both drugs was likely mediating the behavioral effect. The authors did not attempt to test what mechanisms were responsible for the remaining behaviors due to logistical limitations. Considering the many mechanisms of action known for CBD and the fact that none is likely to singlehandedly explain all the effects observed, such an endeavor would have been prohibitively long.

Several other issues remain to be tackled in future research, including the tracing of HUF-101 toxicity profile in different animal models, the study of its pharmacodynamic parameters, and assessing how well these effects generalize to other types of assays that measure similar aspects of behavior. Only after addressing these issues will any prospects of clinical human trials be feasible. For now, this new compound remains an interesting scientific finding with potential applications in the development of more effective cannabis-based medicines.

Source : New Lift

Oregano Oil : One the most effective antibiotics known to science

Oregano oil is the ultimate antibiotic. Oregano is a powerful herb with unique healing properties. Did you know that oregano has eight times more antioxidants than apples and three times as much as blueberries? Antioxidants are needed to protect our body against free radical damage. They boost the immune-system naturally. Oregano Oil is the most potent plant oil in the world!

The distribution of oregano oil started in Ancient Greece. In Greek the word oregano is translated as joy of the mountains. The Greeks were first to use oil for medicinal purposes, such as a powerful antiviral, antibacterial, antiseptic, antifungal agent and also as a remedy for pain, and inflammation. It was the main antibacterial tool used by Hippocrates. Oregano leaves were traditionally used to treat illnesses related to the respiratory and digestive systems.

The Complete Book of Essential Oils and Aromatherapy: Over 600 Natural, Non-Toxic and Fragrant Recipes to Create Health — Beauty — a Safe Home Environment

Oregano Oil is The Ultimate Antibiotic
Main Ingredients Oregano Essential Oil is a mineral density powerhouse. It contains calcium, magnesium, zinc, iron, potassium, copper, boron, manganese, vitamins C, A (beta-carotene), Niacin.

Oregano oil contains four main groups of chemicals which are active healing agents.

Phenols including carvacrol and thymol. They act as antiseptics and antioxidants. Terpenes including pinene and terpinene. They possess antiseptic, antiviral, anti-inflammatory and anesthetic properties. Linalool and bonreol are two long-chain alcohols found in oregano oil. They exhibit antiviral and antiseptic properties. Esters include linalyl acetate and geranyl acetate. They exhibit antifungal properties. Although all these compounds possess healing properties, the most significant primary compound found in oregano oil is carvacrol. Scientific research has proved carvacrol to be one of the most effective antibiotics known to science.

Not All Oregano Oil is Created Equal

Real wild Mediteranean Oregano needs to be either of origanum vulgare kind, or Thymus capitatus, which mostly grows in Spain. It is very important to make sure the Oil of Oregano is derived from these two kinds. It also has to have the carvacrol concentration of 70% or more. Most importantly, oregano essential oil does not create harmful strains in the body and does not have side effects the pharmaceutical antibiotics do. Moreover, it is effective against a dangerous and even deadly bacteria, but does not produce biological changes in the body. Oregano essential oil nourishes the body and doesn’t deplete it of nutrients like conventional antibiotics do. And if you look at the statistics, people in the Mediterranean live longer for the most part. Maybe partly because of oregano which is added to most Mediterranean dishes!

Source: livingtraditionally.com

Don’t Laugh. Rectal Suppositories Could Be the Future of Medicinal Cannabis.

Any people can’t help but laugh the first time they hear the phrase “cannabis suppository.” But don’t be mistaken: This method of accessing the active ingredients in the cannabis is no joke. And the benefits are convincing a growing number Europe’s medical patients to make the switch from more traditional methods of consumption.

Until about five years ago, the vast majority of Europeans who treated their ailments with cannabis either smoked or vaporized the plant. But thanks largely to Rick Simpson, a Canadian who treated his cancer with cannabis oil and lived in exile in Eastern Europe between 2009 and 2013, more and more people started to discover the amazing properties of extracts. There was one big problem: Consuming extracts that had a high THC percentage—up to 90 percent in some cases—was overwhelming for many patients, especially those without previous experience with cannabis.
The benefits of suppositories—combined with how easy it is to make them at home—has made them quite popular.
“Some six years ago, after meeting with Rick Simpson, I started to produce extracts and provide them to many sick people. Illegally, of course,” said a producer in the Czech Republic who asked to go by Martin T. “But lots of them could not bear the psychoactive effects of THC.”
This prompted some patients and their caregivers to look for another way of ingesting the medicine. “I tried to infuse cocoa butter—with a little bit of shea butter and coconut oil—with the extract and made rectal suppositories,” Martin said. “Patients immediately loved them, especially those with digestive and urinary issues.”
Rectal suppositories seemed promising for at least two reasons. First, they go to work quickly. Suppositories exert systemic effects when they enter the rectal mucosa, spreading healing compounds quickly through nearby organs and into the bloodstream. Second, it’s an effective way of diminishing the “head-high” psychoactive effects of THC.
The benefits of suppositories—combined with how easy it is to make them at home—has made them quite popular, especially in Central Europe.
Despite the emergence of vaginal suppositories in the U.S., the suppositories Martin makes are for rectal use only. “A vagina has a very sensitive and specific environment, requiring a special gel carrier, which is pretty hard to get,” he explained. About 90 percent of his patients are now using only suppositories, he said, and the results have been amazing.

Source Leafly

Cannabis Appears to Affect Emotional Response to Pain

New study finds that the use of cannabis does not affect major brain changes in regards to pain, but does appear to provide emotional relief.

Chronic pain affects millions of people around the world. The cause of pain can be very hard or even impossible to detect, and it can be difficult to find an effective form of therapy. Even when the cause is clear, it can be a challenge to find a way to effectively combat ongoing pain.

For some patients who struggle with chronic pain, cannabis (also known as marijuana) and cannabis-based medications have been found to be effective. However, others find that it fails to reduce their pain, only bringing about the side effects associated with its use, which, according to the National Institute on Drug Abuse, include “distorted perceptions, impaired coordination, difficulty with thinking and problem solving, and disrupted learning and memory.”

A new study by the University of Oxford, published in the journal Pain, aims to get a better look at what exactly occurs in the brain when someone uses cannabis as a therapy for pain relief. Researchers found that, although some people reported changes in their levels of pain, there appeared to be no significant changes in the parts of the brain that account for the experience of pain. It did, however, appear that cannabis affects the emotional response the patients to pain, but it does not do so in a consistent fashion.

The Expert Take
Dr. Michael Lee of the University of Oxford’s Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), who was involved with the study, spoke with Healthline about how the study was conducted, as well as its implications for patients suffering from chronic pain.

Although the study was limited to a small group of men and examined only one possible THC compound, the study was intended to begin scratching the surface of what occurs in the brain during the use of THC (the psychoactive ingredient in cannabis).

“Patients may be prescribed multiple doses and for much longer periods of time to help them manage pain,” explains Lee. “We studied effects from a single dose of THC in healthy, drug-naïve volunteers for ethical and scientific reasons.”

Source and Method
The study involved 12 men in good health, who were each given a 15mg tablet of either THC or a placebo. THC, or tetrahydrocannabinol, is the ingredient in cannabis that produces a high, and accounts for the popularity of cannabis’ use as a recreational drug.

“THC is the main psychoactive compound of cannabis,” explains Lee. “It has been prescribed in the form of Marinol (US) or Dronabinol (Europe) and also as part of Sativex for chronic pain.”

In order to produce a mild amount of pain in these healthy individuals, one of two types of cream was rubbed into the skin of one leg. One type was a dummy cream that did not elicit pain, while the other contained one percent capsaicin, which causes a painful, burning sensation.

Magnetic resonance imaging (MRI) was conducted four times on each participant—once for each possible combination of cream, placebo, and THC. They were asked to explain to researchers the intensity of their pain, as well as how much it bothered them.

The Takeaway
It was not clear that cannabis had any actual effects on the parts of the brain that signal pain, but it did appear to aid some study participants in their emotional experience of that pain.

“Cannabis may influence the emotional aspect (‘the hurt’), rather than the sensation of pain,” explains Lee. “This sort of pain relief may depend on how the amygdala (the brain region linked to fear) reacts to the drug. That means that not everyone can benefit from the effects of cannabis on the brain.”

The researchers found an apparent correlation between the effectiveness of THC for pain relief and a certain connection in the brain—namely, the strength of the connection between the right amygdala and the primary sensorimotor area, which is part of the brain’s cortex. If this correlation is, in fact, present, it may allow doctors to determine in advance whether THC will be effective as a form of pain relief for certain patients. This will, however, require long-term studies, and would also require the participation of patients suffering from chronic pain.

Researchers determined that, although the burning sensation did not appear to change, THC did appear to make the pain less bothersome in some patients. However, out of the 12 participants, only six said there was an actual change in the degree to which their pain bothered them.

Other Research
A 2002 study in Pain Research & Management took a look at therapeutic cannabis use among patients experiencing chronic pain. Most of the patients surveyed in the study reported improvement in pain, mood, and sleep.

Future studies will need to examine the effects of THC over a longer period of time, and in patients who actually experience chronic pain, as opposed to the healthy men surveyed in the Oxford study.

“We do need longer-term studies to help predict which patients, or what sort of pain, might respond positively to cannabis-based medicines,” says Lee. “We also need to understand the long-term risks of cannabis in these patients.”

Although the findings of the Oxford study will likely impact future research on THC and pain relief, it is unclear how the findings will affect the dialogue surrounding the use of cannabis. “The findings are of interest scientifically, but it remains to be seen how they impact the debate about use of cannabis-based medicines,” says Lee in a press release for the study.

Source: Health Line

Study: Cannabidiol (CBD) May Prevent Degenerative Disc Disease

What is Intervertebral Disc Degeneration/Degenerative Disc Disease?
Intervertebral discs sit between each vertebra (bone segments of the spine) and are comprised of fibrous cartilage. They act to stabilize and mobilize the spine, and also to absorb shock that results from movement, in order to prevent damage to the body. When intervertebral discs are damaged and degenerate (most commonly in the regions of the neck and lower back), the spine loses stability and mobility, and several complications can arise, including osteoarthritis (vertebrae start to rub together), herniation (discs bulge out and may compress nerves), and spinal stenosis (the spinal canal, where the spinal cord travels, gets smaller and may also compress nerves). Symptoms experienced with these complications may include pain, numbness, tingling, and disordered movement and can be severely debilitating.
vertibraeIntervertebral disc degeneration may occur as a result of several processes, including inflammation and decreases in available oxygen, water and sugar chains (a main component of intervertebral discs). Intervertebral disc degeneration occurs more commonly as people age, and is more likely to develop in those who are obese, smoke cigarettes, who frequently perform heavy manual labor, or who experience trauma from a fall.
Given that the spine is the body’s main frame of support, maintaining spinal health is vital to leading a long and active life.
Researchers Study CBD-Based Treatments
The results of a controlled animal study published in PLoS One in December 2014 suggest that administration of cannabidiol (CBD), a non-psychoactive cannabinoid (known for its numerous potential health benefits including inflammation and pain reduction), may be useful in reducing damage caused by intervertebral disc degeneration.
Researchers studied 19 rats and created a model of human intervertebral disc degeneration by using needle punctures to injure intervertebral discs of the tailbone area of the rats’ spines. The subjects were then split into three groups, and each immediately treated with a different concentration of CBD (30, 60, or 120 nmol). The discs were then examined using MRI (magnetic resonance imaging) and histologically (under a microscope, in order to see the injuries in finer detail).
Conclusion
MRI analysis showed that treatment with 30 and 60 nmol of CBD did not result in improvements in injury. However, the group that had been administered 120 nmol of CBD did experience reduced damage. By MRI, improvements were noted within 2 days of injury/treatment, and they endured until at least day 15 post-injury/treatment (the last day of the experiment) when examined by MRI and histologically.
Although the sample size of this study was very small, the researchers note, “Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration… Although further research is necessary to clarify the mechanisms involved in CBD effects, the present results suggest the possibility of its use for disc degeneration treatment.”

Source: Medical Jane

HEMP PASTA AND PESTO WITH ROASTED TOMATOES

Ingredients:
Pasta
2 cups hemp flour
2 cups all-purpose flour
1 tsp salt
4 eggs
1 Tbsp hemp oil
Pesto
1/4 cup fresh organic lemon juice
1 cup organic almonds, toasted
2 cloves garlic
1 cup roughly chopped fresh basil
1 cup hemp oil
1 cup hemp seeds
salt and pepper
Roasted Tomatoes
1/2 cup olive oil
4 cups cherry tomatoes, halved
2 bulbs garlic
salt and pepper
Method:
Pasta
1. In a bowl, sift flours and salt. Put mixture on a wooden board or countertop.
2. Make a well in the centre and drop in eggs and oil.
3. Using your fingers, gradually mix flour into liquid until stiff dough forms.
4. Knead for 15 mins.
5. Cover and rest for at least one hr.
6. Using a pasta machine, roll dough from thickness 1 to 4.
7. Cut into desired shapes.
8. Using a cooling rack, allow dough to dry for 30 mins before boiling.
Pesto
1. In a food processor, purée lemon juice, almonds, garlic and basil.
2. While machine is running, drizzle in oil.
3. Transfer contents to a bowl and fold in seeds.
4. With salt and pepper, season to taste.
Roasted Tomatoes
1. Preheat oven to 350˚F.
2. Cut tops off garlic bulbs and drizzle with olive oil.
3. Wrap bulbs in tin foil and roast for 35-40 mins.
4. Lower oven to 275˚F.
5. Squeeze garlic from skins and chop.
6. In a roasting pan, toss tomatoes, oil, salt and pepper. Cook for 30 mins.
7. Transfer tomatoes to a bowl and mix in roasted garlic.
Assembly
1. Boil pasta for 4 mins until al dente.
2. In a bowl, mix tomatoes and a couple spoonfuls of pesto.
3. On a plate, top pasta with tomatoes and pesto.
4. Drizzle with 1-2 Tbsp hemp oil.

Source:Ciao Winnipeg

Hemp Avocado sweet Smoothie

Ingredients:

1 ripe avocado
1 banana, sliced and frozen
½ cup quick cook (porridge) oats
1 cup almond milk ( or hemp milk )
½ cup low-fat greek yogurt
1 tablespoon shelled hemp seeds, plus more as desired
1 tablespoon hemp chia

Method:
Blend everything in a blender and mix until smooth. Sprinkle on additional hemp seeds on top and serve.

Enjoy

Cannabis Coconut Oil- Easy Recipe Combats Pain, Nausea, Seizures and More

Virgin coconut oil on it’s own is one of the most amazing products for health care and beauty regimens. I use it to deep condition my hair, moisturize my skin, bake delicious cookies, wipe make up off, apply as a lip-balm, etc.

Coconut oil has tons of health benefits and uses both internally and externally. It can be applied externally to heal skin and hair from damage, or ingested to help improve memory, fight cancer, ease digestion, boost the immune system, reduce inflammation, cure UTIs, eliminated kidney infection, protect the liver and more.

Making a Great Thing Even Better

One way to make coconut oil even more useful is by infusing it with the medicinal properties of marijuana. Marijuana and coconut oil, when combined properly, create a symphony more beautiful than chocolate and peanut butter (it’s just so much sexier than PB&J, people).

Coconut oil is full of natural saturated fats. Don’t worry, these are the ones that increase the HDL (good cholesterol) in your body and help convert the LDL (bad cholesterol) into HDL, a key ingredient to a healthy heart.

The tetrahydrocannabinol (THC) and cannabidiol (CBD) in marijuana, the two cannabinoids that give marijuana it’s healing properties, are very fat soluble. The high concentration of fatty acids present in coconut oil creates a perfect adhesive for the cannabinoids, that bond with the fatty molecules.

How Cannabis Coconut Oil Can Help You

The results of the cannabis coconut oil are much more potent than other butters/margarines/oils, highlighting the medicinal properties of the flower. Cannabis can be used to cure all types of illnesses, depending on the strain, but you have to know how to choose the right one.

Strains heavy in THC are best for treating pain, PTSD, nausea, lack of appetite/eating disorders, asthma, glaucoma and sleep disorders.

Other strains that are higher in CBD can be used to combat anxiety, pain, tumors, cancer, seizures, psychosis and neurodegenerative disorders.

The Marijuana Strain Makes a Difference

Flowers in the sativa family have a high CBD:THC ratio, so they have an energizing affect that stimulates the mind and promotes optimism.

Due to the high CBD content, they are often used to treat depression, ADHD, and appetite loss. Conversely, those in the indica family have a high THC:CBD ratio. The high THC content gives indica strains a sedative effect that helps with anxiety and sleep disorders.

There are many different hybrid plants that fall on a spectrum of traits from both plant families.

Decarb the Marijuana Before Making your Oil

Decarboxylation is a super simple process. Whenever you use marijuana for cooking or recipes like the one below, make sure you follow these easy steps:

Preheat the oven to 240° F. / 115° C.
Break up cannabis flowers and buds into smaller pieces with your hands. We use one ounce, but you can elect to do more or less.
Put the pieces in one layer on a rimmed baking sheet. Make sure the pan is the correct size so there is not empty space on the pan.
Bake the cannabis for 30 to 40 minutes, stirring every 10 minutes so that it toasts evenly.
When the cannabis is darker in color, a light to medium brown, and has dried out, remove the baking sheet and allow the cannabis to cool. It should be quite crumbly when handled.
In a food processor, pulse the cannabis until it is coarsely ground (you don’t want a superfine powder). Store it in an airtight container and use as needed to make extractions
How to Make Cannabis Coconut Oil

In order to prepare Cannabis Coconut Oil, place one gram of de-carboxylate marijuana for every ounce of virgin coconut oil. Place the crushed marijuana in a glass jar and add the coconut oil. Put the lid on the jar, seal it well and put it in a pan full of water. Slowly heat the water and keep it on a below boiling level for 60 minutes.

In this way you will keep the oil safe from overheating.

Next, use a strainer to strain the mixture to eliminate the solid elements. Make sure to squeeze the juice from the cannabis. Some people use cheesecloth to strain the mixture properly.

Once you are done with this procedure, you can eat the cannabis coconut oil like that or use it in other foods or apply it as a lotion. Feel free to cook with this treated oil, only when the temperature is lower than 315 F. That is the temperature of the point of boiling of the active compound of marijuana. Obviously, if you use higher temperatures the effects will be gone.

Source : Wise Mind Healthy Body