New compound eases pain like marijuana, without the ‘high’

Opioids and medical marijuana are considered effective treatments for chronic pain, but the drugs carry significant risks. In a new study, researchers reveal a drug compound that is just as effective for alleviating chronic pain, but without the side effects.

Chronic pain – defined as pain that persists for at least 12 weeks – is estimated to affect more than 76 million Americans, according to the National Institutes of Health.
Opioids are among the most commonly prescribed medications for chronic pain in the United States; in 2012, physicians wrote around 259 million prescriptions for the drugs – the equivalent to one bottle of pills for every adult in the country.

Though opioids might be effective for pain relief, their use has become a major public health concern. Opioids are addictive, and in 2014, the drugs were responsible for more than 28,000 deaths in the U.S. At least half of these deaths involved a prescription opioid.

Studies have also suggested that marijuana is an effective pain reliever, and a number of U.S. states have legalized its use for medicinal purposes. Still, marijuana use may pose a number of short- and long-term side effects, including altered sensory perceptions, hallucinations, delusions, impaired motor function, and memory loss.

The risks associated with the use of opioids and medical marijuana have fueled the search for safer, effective pain medications. Andrea Hohmann, of Indiana University in Bloomington, and team believe they may have moved one step closer to a potential candidate: a compound called CB1 PAM.

The researchers recently presented their findings at the Society for Neuroscience’s 46th annual meeting, held in San Diego, CA.

CB1 PAM led to long-term pain relief in mice
For their study, the team administered a chemotherapy drug called paclitaxel to mice, which is known to cause nerve damage and pain in up to 40 percent of cancer patients.

The rodents showed hypersensitivity to cold and mechanical stimulation to the paws, the team reports, which is an indicator of increased pain.

Next, the researchers gave the mice a synthesized CB1 positive allosteric modulator (PAM) – a compound that binds to a cannabinoid receptor in the brain called CB1. This is the receptor that marijuana’s primary psychoactive ingredient tetrahydrocannabinol (THC) targets to alleviate pain.

CB1 PAM was administered in combination with endocannabinoid breakdown inhibitors – drugs that increase endocannabinoid levels in the brain, which are natural pain-relieving compounds.

The researchers found that the rodents showed no pain in response to cold and mechanical stimulation after receiving CB1 PAM and behaved like normal mice.

Importantly, CB1 PAM did not trigger the “high” associated with marijuana use, and unlike the marijuana compound THC and endocannabinoid breakdown inhibitors, CB1 PAM showed long-term efficacy for preventing pain.

What is more, the team found CB1 PAM alone did not activate the brain’s reward system, suggesting the compound is unlikely to lead to recreational abuse and addiction.
While further research is clearly required, the investigators say their results show it is possible to target cannabinoid receptors and reduce pain, while avoiding potentially seve.

Source: Medical News Today

Written by Honor Whiteman

RAW HEMP SEED BARS WITH CACAO DRIZZLE

INGREDIENTS:

FOR THE BAR

2 cups organic almonds
1 1/2 cup organic hemp seeds
1/2 cup organic almond butter
1/2 cup organic raw honey (or maple syrup for vegan)
1/4 teaspoon organic vanilla bean powder
1/4 teaspoon Himalayan pink salt

FOR THE DRIZZLE

2 tablespoons organic coconut oil (melted/liquid)
2 tablespoons organic raw honey (or maple syrup for vegan)
2 tablespoons organic raw cacao powder

METHOD:

For the bars
Step 1 Put all the ingredients for “the bar” into a food processor and process until well combined and crumbly texture.

Pour mixture into an 8 x 8 glass dish and press down firmly with your hands/fingers.

Put into the freezer for approximately 15 – 30 minutes to harden and firm up.
For the drizzle
Step 2 Combine the ingredients for “the drizzle” in a small mixing bowl and stir until well combined.

Using spoon, take a spoonful at a time and drizzle over the tops of the bars.

Cut into either squares or bars.

They keep their shape best if stored in the refrigerator or freezer.

Enjoy!

PEANUT BUTTER HEMP GREEN SMOOTHIE

Ingredients:

1/2 cup unsweetened non-dairy milk (I like almond milk)
1 large ripe banana, fresh or frozen
2 tbsp natural peanut butter
2 tbsp hemp seeds
2 cups greens (I use spinach but kale, romaine, arugula all work)
1 cup milk ( or hemp milk )

Method:

Add ingredients to a blender in the order listed.
Blend until smooth.

Enjoy

Mini Chocolate Hemp Pecan Tarts

Ingredients :

For Tart Crust
2 Cups of unsalted butter
5 Cups all-purpose white flour
2 Cups hemp flour
1 Cup of water
For Tart Filling
½ Cup of sugar
1 Tbsp all-purpose white flour
4 Large eggs
1 Cup of corn syrup
1 Tbsp unsalted butter
2/3 Cup chopped pecans (or you can use walnuts)
2/3 Chocolate chips (or chopped dark chocolate)
1.5 Cups pecan halves
To Make Crust
1. Prepare tart pans by greasing with PAM spray or greasing with butter and flour. In a mixing bowl, combine butter and flour, gradually sprinkling in water and mixing together until dough forms.
2. On a floured surface roll out the dough to a 1/8” inch thickness. Cut 6-inch circles and fit into the prepared tart pans, cutting off the extra on the sides. If you have individual tart pans/cups, place them all on a baking sheet now. Preheat your oven to 325 F.
To Make Filling
1. In a large mixing bowl, sift together flour and sugar. Mix in eggs, corn syrup, and butter until well combined. Mix in the chopped pecans and chocolate chips.
2. Using a soup ladle, evenly divide the mixture between the tart pans. Place pecan halves at the top of the tartlets and bake for 25 minutes or until the edges of the tarts are golden. Transfer to a wire rack and allow to cool overnight.
Enjoy

Creamy Chocolate Hemp Smoothie

Ingredients:

2 cups almond milk (see note)
2-3 pitted large Medjool dates, to taste (I use 2)
3 tablespoons unsweetened Dutch-processed cocoa powder
3 tablespoons hulled hemp seed
1 large peeled and frozen banana
1/4 teaspoon cinnamon
4 large ice cubes

Method :
Add all ingredients into a high-speed blender and blend until super smooth.

Enjoy 

CBD and Acne: What You Need to Know

Remember back when we thought acne was just a teenage thing? That was hilarious. It turns out that it happens in the teenage years….and the decades that follow. It’s persistent, annoying, and totally affecting all of our careers as supermodels.

Acne: In a Nutshell
Almost everyone has experienced acne at one time or another: it’s the most common skin condition in the country. And, while it is frequent during the high school days, it can happen at any age, from babies to Baby Boomers, and appear in a variety of areas on the body.
Interestingly, acne is an umbrella term not limited to just pimples: blackheads, whiteheads, cysts, nodules, and papules all fall under the definition as well. It’s caused when a pore on your skin becomes clogged with dead skin cells. Bacteria sometimes plays a role too, inflaming the skin until it’s red and swollen.
The surest way to get acne is to schedule a photography session: senior photos, wedding shots, birthdays pics – pimples have a way of appearing out of nowhere an hour before the camera clicks. But, the true causes of acne include hormones, certain medications, and diet (most often those high in dairy and carbs). Stress doesn’t technically cause it, but it does increase cortisol, a hormone that releases oil and makes skin more inviting, all but asking pimples to pop on over.Girl with Acne staring in a mirror
While some people believe acne-suffers must simply let it run its course, medical professionals disagree. If untreated, it causes scarring and dark spots. It even influences self-esteem and plays a role in depression.
Yes, it’s the pits. But, now, it’s also the pot.
A Marijuana Makeover
While you probably shouldn’t replace your dermatologist with Dr. Mary Jane, cannabis possesses a natural talent for skincare. In particular, the cannabinoid CBD has proven to be effective against acne, challenging Clearasil in the race of the face.
CBD acts on receptors that help reduce inflammation as well as anxiety (thus reducing the hormones conducive to outbreaks). A study conducted by the Journal of Clinical Investigation and the National Institute on Health found that CBD also offered antiproliferative effects (making it able to stop the spread of cells) and skin regenerating properties.
The study based its theory on the use of CBD on sebaceous glands (these glands secrete oily sebum, which obstructs pores). The experiment found that CBD acted as a sebostatic agent, giving it the ability to reduce sebum and, in the process, acne.
Research conducted by the Federation of American Societies for Experimental Biology uncovered similar findings: cannabinoids are responsible for lipid products and, ultimately, helping the skin regulate itself against dryness and blemishes.
What’s more, both studies found that the benefits of CBD might not be limited to Z-I-T. It may also possess anti-aging effects and treat more serious conditions like dermatitis and psoriasis.
Cannabis as Acne Treatment
Although the above studies attest to the acne-fighting powers of cannabinoids, it’s not a condition yet treatable with cannabis, at least not on a regulated level. In order to become an official condition in which medical cannabis is authorized, the policy-makers associated with health must consider the research.Skin lotion next to marijuana plant Acne simply isn’t a priority. It’s easy to see why: it’s hard to focus on curing the cosmetic, when you can focus on curing cancer.
Still, this doesn’t mean anyone looking for a marijuana makeover is up a creek without a paddle (or a powder puff). Luckily, there’s this thing called the internet where you’ll find almost any product you want.
The Products Worth Trying
Anyone interested in using cannabis-based treatments can purchase them through places like eBay, GNC, and, naturally, Amazon. Because the industry is new, there isn’t a go-to company the way there is for things like organic cleaning products (Seventh Generation, for example) or online shopping (the aforementioned Amazon). Even so, there are certain products worth a dabble. These include:
Cibaderm: The first commercially available beauty product to contain 100 percent organic CBD, it’s high in antioxidants and balanced for a variety of dermatologic needs. Its product line isn’t just skin deep, either; they offer serums for hair and nails too.
Carun All-Purpose Hemp Ointment: This ointment is designed especially for problems like acne. It’s also helpful for eczema, cold sores, irritated skin, burns, and insect bites.
Organic Hemp Hippie Body Butter Cream: The ingredients might make you smear it on a cracker, rather than your skin. It contains coconut, apricot, hemp oil, sunflower oil, and shea butter. This product offers acne treatment, as well as anti-inflammatory, anti-oxidant, and oil balancing properties.
Smoking Marijuana for Acne
While CBD may hog all the glory (at least in this article), pot contains hundreds of cannabinoids and terpenes. These work together as antioxidants and anti-stressors. All of this is conducive to health of body and mind. This educes the outbreaks of acne and, really, everything else. But this doesn’t mean you should use your pipe as your pimple popper. There’s more to consider.
As many people know, smoking tobacco is something that ages you: The Marlboro Man stopped getting carded at the local bars when he was only 15. Cigarettes simply don’t mix with the cosmetic. But is it the same for joints?
THC offers some protection from the harmful byproducts of smoking anything. Yet, the net effect of joint after joint could potentially decrease collagen and lead to an older-looking appearance. Woman vaporizing This doesn’t mean you need to choose between Mary Jane and Father Time. Instead, use a vaporizer or, at the very least, a bong.
Bongs reduce many of the harmful byproducts of smoke. Vaporizers, because they heat marijuana at lower temperatures than bongs (or joints, for that matter), eliminate even more.
None of this insinuates that rolling a joint or lighting a pipe is suddenly going to result in people asking you about the good old days, but if you’re concerned about wrinkles, consider a vaporizer. Save the skin and, if you’re in charitable mood, the whales too.

Source : Wiki Leaf

VEGAN HEMP PARMESAN

Ingredients :

½ cup hemp seeds
2 tablespoons nutritional yeast (or to taste)
½ teaspoon salt (or to taste)

Method:
In a blender or food processor, combine all ingredients. Pulse the blender about 15-20 times, scraping down the sides if needed, just until the hemp seeds taken on a slightly powdery texture and are well-combined with the nutritional yeast.
Leftovers keep for at least a week in an airtight container in the refrigerator.

Enjoy

VEGAN HEMP PROTEIN SMOOTHIE

Ingredients :
3 tbsp Hemp Protein
Non-Dairy Milk, to blend (about 1 cup)
3 large Bananas, peeled & frozen overnight (3+ cups)
1 cup Spinach, lightly packed
1½ tbsp Cacao or Cocoa Powder
1 tbsp  Almond Butter

Method:
Measure and blend all ingredients at a high-speed until smooth. Adjusting liquid as needed, to desired consistency. If you have a low-speed blender, I recommend adding the spinach and non-dairy milk first. Blend those until no chunks are left, then add everything else.
Serve immediately, or pour into ice cube trays to blend with other smoothies as a smoothie starter.

Enjoy

 

ORANGE VANILLA HEMP CHIA PUDDING

Ingredients:

1/4 cup chia seeds
1/4 cup hemp seeds
1 cup almond milk ( or almond milk)
2 tablespoons maple syrup
1 whole vanilla bean
1 whole vanilla bean
1 cup orange juice
1/4 cup walnuts

Method:
Step One

Using a real vanilla bean here is crucial. It adds a completely different (and better) flavor than the extract stuff. To do this, use a sharp knife to slice the vanilla bean lengthwise and use a spoon to scrape out the millions of tiny seeds contained within each half. In all, you should have about 1/4 teaspoon of a gooey paste that contains the seeds. Set this aside momentarily.

Step Two

Prepare the orange juice Orange is powerful stuff you’ll ideally want it to be grated or chopped very finely so that it blends smoothly in the pudding. Large pieces, like I have on top of my pudding, are too overpowering and hard to eat (oops). The best way to do this is to use the finest side of your box grater and grate about 1/2 teaspoon of your orange’s skin. If the strands are still too big, take a sharp knife and further chop until it is very fine.

Step Three

In a bowl, combine the chia seeds, hemp seeds,hemp milk, maple syrup, vanilla seeds, and orange juice. Whisk constantly for at least 90 seconds. Why whisk? A gel will begin to immediately form around the outside of each seed. If the seeds are stuck together, you’ll end up with chia clumps instead of a fluid pudding consistency. Stirring vigorously at the beginning helps avoid this.

Step Four

Stick the pudding in the fridge for 6-12 hours (overnight works well) to let the magic happen. The next morning, give the mixture another vigorous stir, divide it into serving bowls (or just eat it all yourself), and top with chopped walnuts and a drizzle of maple syrup.

Enjoy

TURMERIC BANANA HEMP SMOOTHIE WITH GINGER

Ingredients:

2 medium-sized bananas
1½ cups Vanilla Almond Milk, Unsweetened
2 tbsp hemp seeds
½ tsp turmeric
½ tsp ginger, minced
½ tsp ground cinnamon
1½ tbsp honey
½ tsp vanilla extract
6-8 ice cubes
Method:
Add all ingredients to NutriBullet or Blender, blend 20-30 seconds or until smooth and creamy, top with additional hemp seeds and turmeric if desired.
Enjoy