Things You Didn’t Know About CBD Oil For Dogs

Holistic vets have been sending us some interesting reports about the benefits of CBD oil for dogs in their care …

A senior Staffordshire Terrier had a 6cm mammary tumor and metastasis  that disappeared in 3 months and didn’t come back …

A Jack Russell Terrier had a severe heart murmur and painful arthritis and, after a month, he wanted to go for long walks and his murmur was much improved …

These are two examples of how Australian veterinarian Edward Bassingthwaighte discovered how CBD oil could be a critical part of his holistic veterinary practice. “I simply can’t explain the improved heart murmur” says Bassingthwaite. “They normally don’t get better.”

Related: How Cannabis Can Help Your Dog

CBD Oil For Dogs: What You Might Not Know

The results seem to be in … researchers are turning their attention to this herb and, so far, they’re finding there’s lots to like. And just as CBD has helped humans, your dog can reap the same health-boosting (and even life-saving) benefits.

Let’s look at the 10 things you might not know about this often misunderstood herb and the research that shows its promise in helping dogs with a variety of common health issues …

1. CBD Is Not Psychoactive

CBD (cannabidiol) is a compound found in cannabis and hemp. THC (tetrahydrocannabinol) can also be found in cannabis and it’s this compound that gives marijuana its psychoactive properties. Most CBD oils are just that … the beneficial CBD without the THC. And they typically come from hemp, not marijuana. In short, your dog won’t get “high” from CBD oil … he’ll get the relaxation without the intoxication.

And speaking of relaxation …

2. CBD Oil Reduces Anxiety

Does your dog suffer from separation anxiety or noise phobias? CBD has been extensively studied for its effect on stress and anxiety. In humans, it’s been found to:

3. CBD Can Fights Cancer

CBD and other substances found in hemp and cannabis have been found to have an anti-tumor effect. CBD has even been shown to stop cancer cells from growing and increased tumor cell death.

  • CBD helps the immune system’s killer cells to cause cancer cell death.
  • CBD kills cancer cells by blocking their ability to produce energy.
  • CBD’s anti-tumor properties slow and inhibit glioma cell growth.
  • CBD can help increase the efficacy of conventional cancer treatment.

4. CBD Can Treat Seizures And Epilepsy

It’s estimated that up to 5% of dogs suffer from seizures. Most dogs with seizures are put on drugs such as phenobarbital and potassium bromide. While they may help control the seizures, they can be extremely harmful to your dog’s liver and other organs. And the drugs don’t work in all cases.

CBD has been shown to work well in drug-resistant epilepsy. In one study, 7 of 8 patients with epilepsy that was resistant to drugs saw a definite improvement within 4 to 5 months of taking CBD.

And a survey of children with treatment-resistant epilepsyfound that 84% of the children taking CBD had a reduction in the frequency of seizures.

5. CBD Relieves Pain

The cannabinoids in CBD work so well for pain that scientists are considering it as a new class of drug for the treatment of chronic pain. Studies show CBD to be very effective for:

6. CBD Can Help With Inflammatory Bowel Disease

Animal studies show that CBD can prevent colitis (IBD) and restore normal gut motility in inflammatory bowel disease.

CBD also has antibiotic properties, including Staphylococcus Aureus (MRSA).

7. CBD Reduces Chronic Inflammation And Autoimmune Disease

CBD has been shown to decrease the production and release of inflammatory cytokines that can cause allergies, hypersensitivities and autoimmunity. It can also suppress something called Th17 dominance, which is a major cause of autoimmune diseases.

CBD also inhibits the production of inflammatory macrophages and decreases chronic inflammation.

CBD is also a powerful antioxidant that’s shown to be more powerful than vitamins C and E.

8. CBD Can Protect The Nervous System And Help With Neurodegenerative Diseases

For dogs suffering from degenerative myelopathy and other spine and nerve issues, CBD shows a lot of promise. It’s been shown to help patients with Amyotrophic Lateral Sclerosis (ALS), Alzheimer’sand Parkinson’s disease by protecting the brain cells from toxicity.

For senior dogs, CBD has been shown to protect the brain from cell death caused by free radicals and toxins.

9. CBD Increases Appetite And Helps With Nausea

If you have trouble getting your dog to eat, CBD may help. The National Cancer Institute reports that CBD increases appetite and carries this extra benefit, in addition to controlling cancer.

In animal studies, CBD has also been shown to help with vomiting and nausea, even when they’re the result of toxins and drugs.

10. CBD Promotes Cardiovascular Health

Just as veterinarian Dr Bassingthwaighte discovered, CBD has been linked to heart health. Studies show it can reduce the damage from damaged blood vessels and irregular heart rates, protect blood vessels from damage and dilate the arteries, and reduce heart rate and blood pressure associated with stress and anxiety.

Bonus: CBD Oil For Dogs Is Legal And Safe

With so many studies showing the health benefits of CBD, the most encouraging result is that CBD appears to be safe, even when taken in high doses and over extended periods of time. It can decrease the activity of liver enzymes used to metabolize many prescription drugs, so if your dog is on medication, you might want to check with your holistic vet before using CBD.

Most CBD oil for dogs and other pets is derived from hemp oil, so it contains no or very small traces of THC. Because of this, all 50 states have approved the use of hemp-based CBD for human and animal products.

The bottom line is, CBD oil could be a healthy (or even life-saving) herb for your dog. More and more pet owners and holistic vets are drawn to its diverse and marked health benefits and they feel good knowing the side effects are mild and animals don’t appear to build up a tolerance.

Choosing A Good CBD Oil For Your Dog

Not all CBD oils are the same … you’ll want a high quality CBD oil that works, so here are a few things to look for:

  • Make sure the product is organic: If it isn’t organic, your CBD oil contains pesticides, fungicides or solvents.
  • Don’t cheap out: The higher the quality and purity, the higher the cost. Don’t price shop … make sure your CBD oil is free of additives and has a good amount of CBD.
  • Get the analysis: Ask for a lab analysis of the amount of CBD in the product. Many CBD oils contain only small amounts of CBD. The manufacturer should provide a certificate of analysis. You’ll also want to make sure there is little or no THC in the product.
  • Buy CBD as a tincture: You can buy CBD in treats but the best form is in a tincture. This way, you can adjust your dog’s dose drop by drop to make sure he gets the most benefit.

Start your dog off slowly but don’t let the naysayers tell you CBD isn’t a good option for your dog … the research is being done and the results are very promising.

Source : Dogs Naturally Magazine – By Dana Scott

Health Benefits of Hemp

Hemp has been called a plant of “major economic importance,” as it grows like a weed, yet can be used in the production of food, personal care products, textiles, paper, and even plastic and construction materials.

Valued since ancient times as a fiber source for textiles, the hemp industry eventually made it to the US, where it flourished in the mid-1800s, through World War I and again briefly during World War II, when the war cut off supplies of fiber.

In the US, the cultivation of hemp has been banned since the 1970s when the federal Controlled Substances Act took effect. The law doesn’t distinguish between marijuana, the drug, and hemp, the plant, despite major scientific differences.

Ironically, the US is the world’s largest consumer of hemp products, yet is the only industrialized country that also outlaws its production. As a result, all US hemp products – a more than $600-million market in the US – are imported. As noted in “Hemp: A New Crop with New Uses for North America:”

“Cannabis sativa [hemp] is extremely unusual in the diversity of products for which it is or can be cultivated. Popular Mechanics magazine (1938) touted hemp as ‘the new billion dollar crop,’ stating that it ‘can be used to produce more than 25,000 products, ranging from dynamite to Cellophane.'”

What’s the Difference Between Hemp and Marijuana
Hemp and marijuana come from the same plant species, Cannabis sativa, but there are noted differences between the two plants. They both contain cannabidiol (CBD), which has medicinal properties. The amount of CBD however, differs greatly between the two.

Dosing, therefore, is dramatically different when you to try to use hemp in lieu of cannabis for medicinal purposes, as the latter, cannabis, is up to 100-fold more potent.

Another difference that appears to matter in terms of its usefulness as medicine relates to differing terpene profiles. Hemp contains very little of these valuable medicinal compounds.

Lastly, there’s the tetrahydrocannabinol (THC) content. THC is the psychoactive component of marijuana; it’s the molecule that makes you feel “stoned.” (While cannabidiol (CBD) also has certain psychoactive properties.

It does NOT produce a high.) By legal definition, hemp cannot have more than 0.3 percent tetrahydrocannabinol (THC) in it. So to summarize:

Hemp has less value for medicinal uses, as it only contains about 4 percent CBD and lacks many of the medicinal terpenes and flavonoids.
It also contains less than 0.3 percent THC, which means it cannot produce a high or get you stoned. While hemp may not have the same medicinal uses as marijuana, it does have excellent nutritional value that may boost health.

Marijuana can act as a potent medicine courtesy of high amounts (about 10 to 20 percent) of CBD, critical levels of medicinal terpenes, and flavonoids, as well as THC in varying ratios for various diseases. The higher the THC, the more pronounced its psychoactive effects.
Genetic Difference Between Hemp and Marijuana Uncovered
If there were still any question over whether or not hemp and marijuana are two different plants, it should be put to rest with the publication of a new study that shows the genetic difference between hemp and marijuana.

Researchers from the University of Minnesota’s (U of M) College of Biological Sciences and College of Food, Agricultural, and Natural Resource Sciences belong to one of the few groups of US scientists that have been granted federal clearance to study cannabis.

After more than 12 years of research, the team found a single gene that is responsible for the genetic differences between hemp and marijuana. As noted by Medical Daily:

“While hemp produces a non-euphoric cannabidiol (CBD) with approximately 0.3 to 1.5 percent tetrahydrocannabinol (THC) concentration, marijuana is packed with between five to 10 percent (or even higher) psychoactive THC concentration.”

The researchers believe they have “indisputable evidence” that hemp and marijuana should be regarded as separate plants.

Nearly half of US states now separate hemp from marijuana. George Weiblen, a professor with a joint appointment in the U of M’s College of Biological Sciences and College of Food, Agricultural and Natural Resource Sciences, said:

“It’s a plant of major economic importance that is very poorly understood scientifically… With this study, we have indisputable evidence for a genetic basis of differences among cannabis varieties, further challenging the position that all cannabis should be regulated as a drug.”

Health Benefits of Hemp
One of the under-appreciated benefits of hemp, at least in the US, is as a food source. Hemp seeds, which are technically a nut and are also known as “hemp hearts,” are rich in healthy fats, protein, and minerals.

Hemp seeds are usually consumed after the hard outer shell is removed, leaving just the soft, creamy “heart” behind. The seeds have a slight nutty flavor, making them incredibly versatile for use in cooking, baking, or for adding to smoothies and salads. Some of their primary health benefits include:

Excellent Source of Nutrition
Hemp seeds are composed of more than 30 percent healthy fats, including the essential fatty acids linoleic acid and alpha-linolenic acid (plant-based omega-3). According to research published in Nutrition & Metabolism:

“Dietary hempseed is… particularly rich in the omega-6 fatty acid linoleic acid (LA) and also contains elevated concentrations of the omega-3 fatty acid α-linolenic acid (ALA). The LA:ALA ratio normally exists in hempseed at between 2:1 and 3:1 levels. This proportion has been proposed to be ideal for a healthy diet.”

Hemp seeds also contain gamma-linolenic acid, which supports the normal function and growth of cells, nerves, muscles, and organs throughout your body.

Hemps seeds are about 25 percent protein and also provide nutrients including vitamin E, phosphorus, potassium, magnesium, sulfur, calcium, iron, and zinc.

Heart Health
Hemp seeds contain numerous heart-healthy compounds, including the amino acid arginine. L-arginine is a precursor to nitric oxide in your body. It has been shown to enhance blood flow and help you maintain optimal blood pressure. Nitric oxide signals the smooth muscle cells in your blood vessels to relax, so that your vessels dilate and your blood flows more freely.

This helps your arteries stay free of plaque. When you have inadequate nitric oxide, your risk for coronary artery disease increases. The gamma-linolenic acid found in hemp seeds is anti-inflammatory, another bonus for heart health. Past research has also shown hemp seeds may help reduce blood pressure, decrease the risk of blood clots, and boost recovery after a heart attack.

Skin Health
Fatty-acid deficiency can manifest in a variety of ways, but skin problems such as eczema, thick patches of skin, and cracked heels are common. Hemp seeds are a rich source of fatty acids in the optimal omega-6 to omega-3 ratio. Research suggests hempseed oil may improve symptoms of atopic dermatitis and potentially provide relief from eczema.

Plant-Based Protein
Although I believe protein from high-quality animal sources is beneficial for most people, if you are following a plant-based diet, hemp makes a healthy source of protein. With all of the essential amino acids and an amount of protein similar to beef (by weight), hemp seeds are an excellent form of plant-based protein.

Two to three tablespoons of hemp seeds provides about 11 grams of protein, complete with the amino acids lysine, methionine, and cysteine. Two main proteins in hemp seed protein, albumin and edestin, are rich in essential amino acids, with profiles comparable to soy and egg white. Hemp’s edestin content is among the highest of all plants. Hemp protein is also easy to digest because of its lack of oligosaccharides and trypsin inhibitors, which can affect protein absorption.

PMS and Menopause Symptoms
The gamma-linolenic acid (GLA) in hemp seeds produces prostaglandin E1, which reduces the effects of the hormone prolactin. Prolactin is thought to play a role in the physical and emotional symptoms of premenstrual syndrome (PMS). GLA in hemp seeds may also help reduce the symptoms of menopause.

Digestion
Whole hemp seeds contain both soluble and insoluble fiber, which may support digestive health and more. Soluble fiber dissolves into a gel-like texture, helping to slow down your digestion. This helps you to feel full longer and is one reason why fiber may help with weight control. Insoluble fiber does not dissolve at all and helps add bulk to your stool. This helps food to move through your digestive tract more quickly for healthy elimination.

Fiber plays an essential role in your digestive, heart, and skin health, and may improve blood sugar control, weight management, and more. Please note that only whole hemp seeds contain high amounts of fiber; the de-shelled hemp seeds or “hearts” contain very little fiber.

Agricultural Hemp Returns to Kentucky
Kentucky was once home to a flourishing hemp industry, but once hemp was outlawed, tobacco became the go-to cash crop. That is now slowly changing once again, as farmers take advantage of the five-year pilot Industrial Hemp Research Program, which was established by James Comer, Kentucky’s commissioner of Agriculture. The program is one recently launched in a number of states, where permission has been granted for industrial hemp to be grown for research purposes. As reported by Newsweek:

“Kentucky led the U.S. industrial hemp business until the end of the Civil War, when production of the crop declined and was generally replaced by tobacco. The Marihuana Tax Act of 1937 put the kibosh on all production and sales of cannabis, including industrial hemp, but the crop saw a rapid resurgence during World War II. Hemp fiber became essential to produce military necessities such as uniforms and parachutes.

The U.S. Department of Agriculture launched its national ‘Hemp for Victory’ program, which provided seeds and draft deferments to farmers. In 1942, farmers planted 36,000 acres of hemp seed. A USDA-funded informational film from that year noted that ‘hemp grows so luxuriantly in Kentucky that harvesting is sometimes difficult.'”

Comer reportedly wants to “single-handedly turn industrial hemp into Kentucky’s No. 1 cash crop” and “breathe new life into family farms that have lost millions of dollars with the fall of the tobacco industry.” Currently, most industrial hemp comes from China, but the plant could bring great economic growth to areas of the US. Among the many products provided by industrial hemp are:

Cannabidiol (CBD), the medicinal compound, which can be extracted from the leaves, blossoms, and stems
Cannabis oil, which comes from cold-pressing the seeds and can be used for cooking, cosmetics, and beauty products
Fiber, which can be used as a substitute for cotton, wood, and plastic, with potentially endless uses
Hemp seeds, which are poised to become a human superfood and could also be used in animal feed
Hemp Could Provide an Environmentally Friendly Alternative to Plastic
Hemp plastic is a “material of the future” that could drastically cut down on the need for plastics and their devastating toll on the environment. In some cases, standard plastics may be reinforced with hemp, which may account for up to 80 percent of the plastic’s weight. Hemp can also be used to make 100 percent hemp plastic, which is recyclable and can be 100 percent biodegradable.

Currently, the most common type of hemp plastics are those infused with hemp fibers, which means less plastic is used and the resulting product is more durable (hemp plastic is said to be five times stiffer and 2.5 times stronger than polypropylene). According to Hempowered.com:

“Using sustainable and renewable natural plant fibers (such as hemp, flax, jute, and kenaf) and through industrial production techniques that mix them into plastics, a new award winning (Biomaterial of the year 2010) granule has been made from a combination of hemp with polypropylene, thus reducing the use of petroleum products.

… Their recoverable component comes from these natural plants and can make up over half of their weight, up to 80 percent. All these features make them suitable for the production of durable products. Hemp Plastic granules offer many advantages like good insulation, dimensional stability at high temperatures, a high thermal deformation temperature, and impermeability… The granules are currently produced for a range of applications in automobiles, construction materials, packaging, toys, and electronic products and launched onto the market in 2010.”

Your health is under siege from every direction. Environmental toxins, ultra-processed foods, EMFs, government-subsidized GMOs and a host of other threats surround us. It is simply not possible to protect yourself unless you are armed with cutting edge health information.

The most complex tasks can be made easy if you just take one step at a time. Taken as a whole, this 30-tip plan makes for a comprehensive guide that can change your life. Just a few of the topics addressed are:

What to eat and when to eat it
Exercise strategies that you can implement today
The power of emotional health
Enhancing your health with essentials like air, sunshine and water
How to get the restorative sleep that your body requires
It may seem that health and wellness are no longer the norm. An opioid epidemic sweeps the country, the obesity rate is skyrocketing, life expectancy is dropping and chronic diseases are rampant. Our communities are being damaged at every level and the only way to reverse these trends is through education and personal example. My 30-tip plan provides you with the tools you need to take control of your health. The time is ripe for revolution — a health revolution.

Source: Dr Mercola

The Importance of Enhancing Your Endocannabinoid System

Cannabis extracts are proving to be remarkably effective against a wide range of diseases for thousands of people. Unfortunately, there is a subset of the population that responds negatively or not at all. Numerous factors influence an individual’s unique response to cannabis medicine, including genetics. Some people may never be able to benefit from cannabis due to rare genetic mutations. However, a major cause of poor experiences may be controllable – the health of the endocannabinoid system.
Cannabis and the Endocannabinoid System
Cannabis is effective because it works through the endocannabinoid system, the function of which is to maintain homeostasis. Given this role, it may often be the best place to target for treating disease, which fundamentally is a state of non-homeostasis. For cannabis to work most effectively, the endocannabinoid system needs to be healthy.
While concentrated cannabis can directly improve endocannabinoid signaling, they are not a cure-all. Other restorative and enhancement techniques must be utilized as well. If the endocannabinoid system can be enhanced before or alongside cannabis extract therapy, the healing results are almost certain to improve considerably.
Enhancing Your Endocannabinoid System
There are two primary ways to strengthen your endocannabinoid system. The first is by avoiding stimuli that deplete endocannabinoid resources. For example, one of the functions the system mediates is the reduction of inflammation. Therefore, eating inflammatory foods like refined grains, sugar, and trans fats can eventually be overwhelming. Stress also recruits endocannabinoid resources, so poor nutrition combined with stress can be especially damaging. Eating an anti-inflammatory diet rich in fruits, vegetables, nuts, seeds, and healthy fat sources like olive oil, fish, and eggs is very helpful, as is engaging in stress-reducing activities like meditation and yoga.
The second pathway to empowerment is consuming things that up-regulate endocannabinoids or cannabinoid receptors. For example, probiotics increase CB2 receptors in intestinal cells and may even potentially reduce pain by acting through those receptors. Exercising, including running and biking, increases endocannabinoid levels. Olive oil, in addition to being anti-inflammatory, may help fight colon cancer by increasing CB1 receptors on the cancer cells.

Source: Medicaljane

Cannabis Oil Capsules May Be Best Treatment For Fibromyalgia

Treatment For Fibromyalgia much like treatments for any and all disease., often starts with the management of symptoms. With this disorder, the symptoms create a string of tender points along the body. Coupling this with extreme fatigue and an inability to sleep and you have a concoction for a drastically poor quality of life riddled with pain and discomfort.

Medical Cannabis Treatment for Fibromyalgia

The prevalence of Treatment For Fibromyalgia goes up as a person ages, yet 80-90% of all cases are women. The symptoms are known to worsen with persistence as it progresses and it is worsened by the weather, illness and stress. One cannabinoid profile that is well suited for this disorder patients has been identified as CBD. It is suggested patients obtain CBD rich medicine. Synergistically coupling a cbd rich oil with one that contains Low THC, there is additional relief provided to patients.

According to a report conducted by the National Pain Foundation and National Pain Report, medical cannabis has been rated as one of the most effective treatment in reducing pain from Fibromyalgia.Many of the 1,300 fibromyalgia patients who responded to the survey said they had tried all 3 of the FDA approved drugs. One patient explained there were far more negative side effects to the FDA approved drugs than there were positive attributes.

When asked about the effectiveness of Cymbalta (Duloxetine), 60% of those who tried the medication stated that it did not work for them, whilst 8% reported it to be very effective. 32% reported Cymbalta helped slightly.Of those in the study who tried Pfizer’s Lyrica (Pregabalin) a whopping 61% reported that there was no relief. 10% reported Lyrica to be very effective whilst 29% said it helped slightly.

Rating Forest Laboratories’ Savella (Milnacipran), 68% of those trailing the drug stated that it didn’t work. 10% reported that it was very effective and 22% reported slight relief.

Comparing the study findings against those who had tried medical cannabis for their this disorder symptoms 62% said it was very effective. Another 33% said it helped slightly whilst only 5% reported no relief.

Source : Women With Fibromyalgia

 

Study Shows Cannabis Protects the Liver From Alcohol Damage

We hear a lot about the effects of cannabis on the brain and body, but rarely do we consider its effects when used in combination with other drugs, like alcohol. Studying the health impacts of both alcohol and cannabis on their own is valuable, but it doesn’t always reflect the public’s use patterns. Therefore, it’s important to understand the impact that the combination of alcohol and cannabis has on health outcomes. A recent study took up this challenge by investigating the effect of cannabis consumption on alcoholic liver disease.
What Is Alcoholic Liver Disease?
Drinking a lot of alcohol over many years causes liver disease by consistently elevating levels of inflammation. Alcohol directly damages liver cells and causes an inflammatory response. Additionally, alcohol disturbs the walls of the intestine, leading to a recruitment of inflammatory cells to repair the damage. These inflammatory cells make their way through the intestine to the liver where they contribute to liver inflammation. Alcohol also disrupts the microbes in the gut, causing them to release toxins into the blood stream that the liver tries to break down and becomes inflamed in the process.
These processes lead to the onset and progression of alcoholic liver disease:
The progression of alcoholic liver disease often brings a disruption of normal gut function, leading to an excess of fat deposits in the liver. This creates a condition known as “steatosis,” or “fatty liver.”
The increase in the cellular stress by the excess of fat cells in the liver leads to a state of constant inflammation of the liver, even in the absence of alcohol. This state is called “alcoholic hepatitis.”
Eventually, this inflammation leads to irreversible liver cell damage. The damage reaches a point where few healthy cells remain and the liver becomes scarred with non-functioning tissue. This stage is called “cirrhosis,” and liver function is severely compromised.
Lastly, the ongoing inflammation for years, if not decades, also increases risk for liver cancer, called “hepatocellular carcinoma.”
These four manifestations characterize the devastating alcoholic liver disease, which turns out to be quite common. Nearly 29% of individuals have had an alcohol use disorder in their lifetime, and among them, 20% develop liver disease. And it can kill you. In fact, those with an alcohol use disorder are 23 times more likely to die from a liver disease. What if there was a way to reduce the risk of alcoholic liver disease in those with an alcohol use disorder?
Indeed there may be, and cannabis may hold the key.
Ten percent of individuals with an alcohol use disorder also have a cannabis use disorder, while even more use cannabis but aren’t classified as dependent consumers. Could cannabis’ anti-inflammatory properties protect against the development of alcoholic liver disease?
Study Findings: The Effects of Cannabis on Alcoholic Liver Disease
In a massive study that included 320,000 individuals with an alcohol use disorder* (of which over 26,000 were non-dependent cannabis users and 4,300 were dependent cannabis users), the scientists revealed that cannabis use protected against developing alcoholic liver disease. The scientists found that regardless of whether people were frequent or infrequent cannabis consumers, cannabis protected against developing each of the four stages of liver disease. Notably, the heaviest cannabis consumers had the greatest protection against alcoholic liver disease.
Specifically, cannabis use was associated with (note: percentages are for combined dependent and non-dependent cannabis consumers):
45% reduction in alcoholic steatosis (fatty liver)
40% reduction in alcoholic hepatitis (inflamed liver)
55% reduction in alcoholic cirrhosis (scarred liver)
75% reduction in hepatocellular carcinoma (liver cancer)
It must be noted that cannabis was most protective in individuals who met the diagnostic criteria for alcohol abuse. Cannabis had less of a protective effect in those who presumably consumed more alcohol and met the criteria for alcohol dependence. Broadly speaking, alcohol abuse is drinking too much too often, while dependence is the inability to quit. In most cases, those who are dependent end up consuming more alcohol throughout their lives. So it appears that cannabis is only protective against alcoholic liver disease to a point; the more you drink, the less cannabis can help.
Cannabis Protects Against Liver Cancer by Reducing Inflammation
Despite the growing excitement of certain cannabinoids in cancer treatment, the scientists concluded that cannabis’ protection against liver cancer mostly came from its ability to prevent cirrhosis. This is therefore a different protective mechanism than halting or killing the cancer directly. Since 90% of hepatocellular carcinoma stems from cirrhosis, cannabis’ block of this critical step illustrates its substantial therapeutic potential to prevent the onset of these life-threatening conditions.
But their results still leave open the possibility for cannabis’ direct anti-cancer effects. The scientists report that cannabis use was associated with a similar reduction in liver cancer in both alcohol abusers and those who were dependent. Since cannabis was less effective at preventing cirrhosis in those with alcohol dependence, it leaves open the possibility that cannabis directly blocked the development of liver cancer independent of its effects on cirrhosis. Additional studies are needed to assess the effectiveness of cannabis’ anti-cancer properties in the liver.
Alcohol Increases Inflammation
Alcohol damages the brain and body by increasing inflammation, and this inflammation contributes to liver disease. The anti-inflammatory properties of the primary cannabinoids, THC and cannabidiol (CBD), lead one to predict that cannabis consumption could reduce inflammation caused by alcohol, and therefore help prevent the development of liver disease.
However, cannabis’ anti-inflammatory effects are not so straight forward in the liver. THC activates cannabinoid type I and type II receptors (CB1 and CB2), while CBD blocks THC’s actions at CB1 receptors and activates CB2 receptors. This distinction is important considering that activating CB1 receptors has pro-inflammatory effects in the liver and leads to liver disease, while CB2 activation has anti-inflammatory effects and protects against liver disease. These effects have been identified in laboratory models of liver disease, but cannabis’ effect on alcoholic liver disease in humans had not yet been assessed.
Cannabis’ anti-inflammatory properties are already being utilized for pain relief as well as treatment for colitis (inflammation of the colon), multiple sclerosis, and arthritis. Balanced THC/CBD strains or CBD-dominant strains may provide even greater anti-inflammatory effects, and hopefully better prevent alcoholic liver disease.

Source : Leafly

 

Cannabis for Diabetes

More than a million new cases of diabetes are diagnosed in the US every year. One in every 10 adults who are 20 years or older has diabetes.

Diabetes can be a debilitating and life-threatening disease that can drastically lower one’s quality of life and require large amounts of time and money to combat.

Diabetics actually have to contend with group of diseases which result from too much sugar in the blood (high blood glucose). Type 2 diabetes is a chronic condition that affects the way the body processes blood sugar (glucose). In Type 1 diabetes, the pancreas produces little or no insulin. There’s also a stage called prediabetes in which blood sugar is high, but not high enough to be type 2 diabetes.

There is no cure for diabetes. Treatments aim at maintaining normal blood sugar levels through regular monitoring, insulin therapy, diet, and exercise.

Progression from prediabetes to type 2 diabetes isn’t inevitable. With lifestyle changes, weight loss, and medications, it’s possible to bring a blood sugar level back to normal.

What are Cannabinoids?

The human body has a vast endocannabinoid system which responds to changes in the body, produces chemicals called endocannabinoids which fit into receptors in cells throughout the body, especially the major organs. This system helps regulate a number of processes including appetite, memory, mood, pain, metabolism, blood flow, and immune response.

Cannabis contains a group of compounds called phytocannabinoids (cannabinoids made by plants). These phytocannabinoids mimic the actions of our own natural cannabinoids.

Cannabis contains around 80 different cannabinoids, most of which have not been widely researched as yet. The most well-known cannabinoids contained in cannabis are THC and CBD. THC is the cannabinoid that is responsible for the high that marijuana users experience. CBD has very similar effects without the high. Both have profound effects on the human body. So profound that 29 states have now passed laws allowing its use in medicine.

Cannabis for Diabetes

Several studies have shown that cannabis improves blood sugar control and helps with weight loss. It also appears to improve carbohydrate metabolism in users.

In July 2013, the editor-in-chief of the American Journal of Medicine, Joseph S. Alpert, M.D., made this statement when releasing his team’s study called “The Impact of Marijuana Use on Glucose, Insulin, and Insulin Resistance among US Adults,” in the American Journal of Medicine:

“I would like to call on the NIH and the DEA to collaborate in developing policies to implement solid scientific investigations that would lead to information assisting physicians in the proper use and prescription of THC in its synthetic or herbal form.”

“Of the participants in our study sample, 579 were current marijuana users and 1975 were past users. In multivariable adjusted models, current marijuana use was associated with 16% lower fasting insulin levels and 17% lower HOMA-IR (insulin resistance). We found significant associations between marijuana use and smaller waist circumferences.”

One of the symptoms of diabetes is called neuropathic pain. There is ample evidence that cannabis increases nerve growth factor and has antioxidant and anti-inflammatory properties that may help relieve pain.

Type 2 diabetics also have a higher risk of depression. There’s a sea of anecdotal evidence that cannabis improves mood and reduces anxiety, plenty of research to back that up.

Senior researcher Samir Haj-Dahmane said: “Chronic stress is one of the major causes of depression. Using compounds derived from cannabis — marijuana — to restore normal endocannabinoid function could potentially help stabilise moods and ease depression.”

There is still a lot to be learned about the effects cannabinoids have on diabetes, however many patients who use cannabis as a supplement to their usual treatment are reporting improvements in their symptoms.

Below is a list of research reports which look at studies on cannabinoids’ effects on diabetes and blood sugar levels.

The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
CBD lowers incidence of diabetes in non-obese diabetic mice
Neuroprotective and blood-retinal barrier-preserving effects of CBD in experimental diabetes
Cannabidiol arrests onset of autoimmune diabetes in NOD mice
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes
The endocannabinoid system in obesity and type 2 diabetes
Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats
Efficacy and Safety of CBD and THC-V on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes

Source : Compfassionate Certification Centers

Cannabis & Alzheimer’s

According to brain experts, cannabis has shown considerable promise for treating the cause of dementia and Alzheimer’s, but federal regulators keep blocking their path toward a cure.

Despite evidence suggesting that chemicals found in cannabis can helpfully clear the brain of buildup that leads to dementia and Alzheimer’s disease, ongoing federal opposition to the drug makes the road to finding a cure a long and difficult one, according to researchers. As the Independent reports, scientists at California’s renowned Salk Institute are expressing concern over the fairly unfounded legal hurdles that keep slowing down their work toward an effective treatment for these fatal diseases, which afflict millions of Americans each year.

Last year, the team published study resultsindicating that the active chemicals or cannabinoids found in cannabis, such as euphoria-inducing tetrahydrocannabinol (THC), can effectively relieve the amyloid protein buildup and cell damage related to dementia using some of the brain’s own protective measures. Unlike methods which seek to remove amyloid buildup from the outside of brain cells, CNBC explained, those explored by Salk researchers work with the brain’s natural endocannabanoids, which prevent cell death, to fight buildup inside cells and resulting inflammation at an earlier stage in the disease.

Given the current lack of safe, effective treatments and the overall low cost and often minimal side-effects of in medicinal cannabis, the studies should be cause for celebration among advocates and caregivers for the millions of Americans who suffer from dementia, and for the over five million whose condition developed into Alzheimer’s disease, the most common kind of dementia, and for which fatality rates have risen by over 70% since 2000, CNBC noted.

According to lead author Professor David Schubert, however, these innovative results would seem a lot more promising if researchers’ next steps weren’t already bound up by federal regulation and red tape. “It’s a totally unexplored area, because researchers have been stopped by the DEA, due to the way the agency classifies marijuana,” Schubert told CNBC. “The result is that basically no clinical trials have been held to test the use of marijuana-based drugs in the treatment of Alzheimer’s or any other neurodegenerative disease. It’s not right that they have that type of say over something that could be very useful.” He continued,People are dying of this disease, and there is nothing out there for them… Marijuana is not physically addictive, although it can be psychologically addictive like, sugar, salt and fat, none of which are classified as Schedule I drugs. It’s ridiculous when in California anyone can legally go down to the corner store and just buy marijuana.

Schubert pointed out to CNBC that the pharmaceutical industry, with its extremely healthy lobbying power in D.C., is likely a major force in creating legal hurdles for researchers. “The pharmaceutical companies want to stop the use of cannabis in the research community because it’s a natural product, so it can’t be patented,” he said. “They can’t make money on it, so they are against it.”

CNBC also noted that, while an estimated one in three seniors will die fighting dementia and a new Alzheimer’s diagnosis is delivered every 66 seconds, the costs of holding back effective treatment don’t just involve human life. The site points to a 2015 study by the National Institutes of Health which found that the overall price of late-stage dementia exceeds that of any other disease, and to recent estimates that the economic cost of caring for dementia and Alzheimer’s patients totalled a whopping $236 billion last year. During a dementia-sufferer’s final five years of life, that could easily amount to upwards of $287,000 annually per person.

Drug companies are still pouring time and research dollars into potential treatments for the diseases, of course, but even mainstream, pot-free methods have found little success and been slow in coming. According to Schubert, that’s because pharmaceutical companies are not just trying to prevent cannabis cures, but also on the wrong track for finding their own. “They are trying to use antibodies to get rid of plaque that is outside the cell, but that is too late in the disease,” Schubert said.

However, while our big, highly evolved brains still have ample ways of holding us back, it is thankfully never too late to change the way we offer support to others, be it from research labs or the very law of the land.

Source : The Independent

CBD Oil for Pain

CBD oil is quickly becoming a mainstream product for chronic pain, stress, anxiety, and other ailments. The cannabis-derived chemical contains safe and natural medicinal benefits without the side effects of NSAIDs, analgesics, or opioids. In fact, many patients who previously relied on Tylenol, Ibuprofen, or Vicodin to control pain found CBD to help cut down on the number of pills needed to function each day. CBD oil is worth a try for anyone looking to relieve chronic pain.

Symptoms of Chronic Pain
Simply put, chronic pain is just pain that never really goes away. Sometimes it’s associated with a larger problem such as arthritis, fibromyalgia, or multiple sclerosis. It can come on in any form of pain sensation whether it be dull, aching, pins and needles, or sensitivity. Nerve dysfunction and inflammation are two causes of chronic pain, which can be genetic or brought on diet and lifestyle habits. In 2015, about 25 million adults were reported as having some form of chronic pain.

How CBD Relieves Pain
CBD oil helps relieve pain through the endocannabinoid system, a complex system that controls a range of metabolic functions. There are many different receptors throughout the endocannabinoid system, but CBD primarily works with CB1 and CB2 receptors.

CB1 receptors exist throughout the brain and central nervous system, controlling essential processes like sleep, appetite, mood, smell, and motor control. CB2 receptors are located in the immune system, peripheral nervous system, gastrointestinal tract, and brain.

CBD works by triggering CB1 and CB2 receptors through various molecular pathways. This produces analgesic, anti-inflammatory, anti-spasmodic, neuroprotective, and even antidepressive effects that help patients suffering from chronic pain. Since these receptors exist all throughout the body, the result is a systemic relief.

How to Consume CBD Oil for Treatment
CBD is most commonly consumed in the form of pure CBD crystals or pure CBD oil, which is usually made with a food-grade oil.

CBD crystals can be dissolved under the tongue, smoked through a vape pen, or smoked through a dab rig. They can even be sprinkled in a joint or on top of a bowl for an added smoke session boost, or into food or beverages.

Many dispensaries sell oil cartridges for vape pens that are free of THC and contain CBD only for immediate relief of pain and inflammation.

Which Conditions Can CBD Help?
CBD has shown positive results when put up against many chronic illnesses, particularly those throughout the immune or nervous system.

Cannabis is recommended for patients with Multiple Sclerosis, a disease with no known cure where the immune system attacks the nerves and spinal cord. One study showed CBD to inhibit the release of inflammatory compounds that cause painful flare-ups.

CBD is also recommended for patients with Crohn’s disease, a chronic condition caused by inflammation of digestive lining. Like MS, Crohn’s has no cure and CBD is recommended to calm pain during flare-ups.

There is a lot of research needed to evaluate how CBD can benefit cancer patients or inhibit tumor growth. However, what we do know is that cancer patients have used cannabis for pain relief, appetite stimulation, and also relief from chemo-induced nausea.

CBD oil is also highly recommended for patients with fibromyalgia, arthritis, and undiagnosed chronic pain.

Pharmaceuticals VS. CBD For Pain
One of the biggest benefits of CBD oil is the potential to reduce the number of pills needed for relief. Most of us can handle Tylenol, Advil, or opioids in moderation. However, these drugs can still lead to gastrointestinal damage, increased tolerance, dependency, addiction, and overdose.

CBD oil does not cause gastrointestinal damage and it is not known to be habit-forming. All it takes for a patient to become addicted to opioids is a 10-day prescription, which can be prescribed for anything from a pulled muscle to a kidney stone.

In states with legal marijuana, some rehab centers use cannabis as a tapering method for patients going through withdrawal.

Source : International Highlife

 

Cannabis-Infused Gum to Relieve Fibromyalgia Pain

Now you can chew cannabis gum to ease your chronic pain
Cannabis is known for its amazing effects on easing pain of all sorts: from irritable bowel syndrome to fibromyalgia to seizures to cancer pains. You name it! Many opt for smoking or eating cannabis to gain pain relief, but soon, you’ll also have an option to chew it.
The cannabis gum is called MedChewRx®, first to be FDA-approved
Axim Biotechnologies has developed the cannabis chewing gum called MedChewRx®. The gum is going through a series of clinical trials, with the goal of gaining FDA and equivalent international approval as prescription medications. Axim’s goal is completing Phase 3 clinical trials in early 2018.
This gum is made with fibromyalgia and multiple sclerosis in mind
MedChew Rx® is being developed as a pharmaceutical drug to treat pain, spasticity associated with multiple sclerosis (MS) and fibromyalgia. The gum is intended to offer patients more consistent relief than existing cannabis-derived products that are smoked or eaten.
MedChewRx® contains 5mg each of THC and CBD
The cannabis gum is formulated with 5 mg of cannabidiol (CBD) and 5 mg of tetrahydrocannabinol (THC). THC and CBD are both natural compounds that are found in the cannabis plant. The chemical compositions of both elements might be the same, but to put it in the simplest form possible, THC is psychoactive, while CBD is not. Both compounds have an impressive list of ways that they support the human body.
99% pure pharmaceutical-grade cannabinoids are used
Axim Biotechnologies imports cannabis from the Dutch Government’s Office of Medicinal Cannabis, extracts and purifies cannabis strains into 99% pure pharmaceutical-grade cannabinoids to produce MedChewRx®.

Until the cannabis gum is out on the market, you can try these cannabis treatment options
1. CBD Oil
CBD oil comes in many forms: tinctures, capsules, and topicals. CBD oil offers therapeutic benefits without the psychoactive properties.
2. Smoking
There are many different strains to choose from. Consult your doctor or research for the right strain for your purpose.
3. Edibles
Cookies, brownies, chocolate, and drinks are just a few of the edible options. Again, make sure to choose the product with the right strain for your use.

Source : DIV Health Academy

Cannabis and Alzheimer’s Disease

Compounds in cannabis may be able to help symptoms of Alzheimer’s disease.Memory gradually declines with age for everyone. But for those with Alzheimer’s disease, memory loss can be so severe that they can lose the ability to recognize their loved ones.Areas of the brain responsible for memory are affected in Alzheimer’s, and these areas are highly regulated by the endocannabinoid system. This system is activated by compounds in marijuana known as cannabinoids.

Cannabinoids, such as THC and CBD, also have anti-inflammatory and neuroprotective effects that may help slow the progression of Alzheimer’s disease.

Here, we discuss the merits of marijuana as a potential treatment for Alzheimer’s disease.

What is Alzheimer’s Disease?
Alzheimer’s disease is a neurodegenerative condition that mostly occurs in the elderly. The disease is progressive, meaning symptoms tend to worsen over time.

Neurodegeneration is the process of losing brain cells over time. It is not known what causes neurodegeneration in Alzheimer’s.

The most well-known symptom of Alzheimer’s is dementia. Initial symptoms of dementia include problems with memory, but gradually expand into other symptoms like language impairments and behavioural changes.

The progression of Alzheimer’s is associated with the formation of plaques in the brain. These plaques form when a compound known as beta-amyloid is released from brain cells into grey matter.

These plaques actually form in the brains of healthy older adults too, but genetic differences in patients with Alzheimer’s cause a significantly higher number of plaques to form.

Can Cannabis Help Alzheimer’s Disease?
Overall, there is not much evidence on whether marijuana can treat Alzheimer’s, but early reports are promising.

There is preliminary evidence that cannabinoids have neuroprotective and anti-inflammatory effects. Because of this, some researchers believe that marijuana may help with Alzheimer’s.

Researchers have investigated the role of the endocannabinoid system in Alzheimer’s disease. The endocannabinoid system is crucial in regulating memory, and scientists believe it may be affected in Alzheimer’s. Since marijuana stimulates the endocannabinoid system, it may be able to offer some benefits.

During the early stages of Alzheimer’s, the endocannabinoid system is blocked by the formation of beta-amyloid plaques. This disruption of the endocannabinoid system is believed to be partially responsible for the early symptoms of memory impairments.

Other evidence has found that cannabinoids can help protect brain cells from damage and prevent cognitive impairments in animal models of Alzheimer’s. This has led to an interest in THC as a potential treatment option. THC is thought to exert its neuroprotective effects by activating CB1 receptors.

Benefits of Cannabis For Alzheimer’s Disease

Cannabinoids reduce inflammation

Inflammation in the brain leads to damage in neurons and is believed to contribute to neurodegeneration in Alzheimer’s.

A 2009 study found that cannabinoids can help regulate inflammation in the brain. The researchers concluded that cannabinoids could someday be used to reduce inflammation in neurodegenerative conditions like Alzheimer’s disease.

Marijuana improves memory

The most well-known symptom of Alzheimer’s disease is the loss of memory. Patients slowly lose the ability to recognize their loved ones, their surroundings, and how to communicate.

A 2012 study showed cannabinoids can help protect brain cells from the beta-amyloid plaques seen in Alzheimer’s disease.

The study used a synthetic cannabinoid called WIN55212-2, which acts on cannabinoid receptors. The researchers observed that the cannabinoid improved memory in a rodent model of Alzheimer’s.

THC is neuroprotective

Like other neurodegenerative disorders, protecting the brain from further damage is an important element in treating Alzheimer’s. Cannabinoids are known to have neuroprotective properties, and researchers are investigating their potential in Alzheimer’s.

A 2016 study used human nerve cells to investigate the effects of THC on beta-amyloid levels.

The researchers found that THC improved the removal of beta-amyloid from the cells. THC also reduced inflammation and protected the neurons from damage. This evidence suggests that THC might be able to reduce the severity of Alzheimer’s disease in humans.

A 2006 study showed that THC might be able to block acetylcholinesterase (AChE), an enzyme that contributes to beta-amyloid plaque production.

Marijuana improves behavioural issues

As Alzheimer’s progresses, symptoms other than memory deficits begin to develop. During the late stages of the disease, behavioural problems such as irritability and aggression become more prevalent.

In a 1997 study, researchers found that THC could reduce behavioural disturbances in Alzheimer’s disease, and improved appetite in patients. The researchers noted that the effects of THC lasted into the placebo period, indicating that THC had long-term benefits.

Another human trial on the impact of THC in Alzheimer’s disease found that marijuana-infused oils could improve behavioural issues.

The study involved 11 patients, and was published in 2016 by researchers in Israel. Delusions, aggression, irritability, apathy, and sleep were significantly improved when the cannabis oil was added to the patients’ treatment regimens.

CBD and Alzheimer’s Disease

When discussing marijuana in a medical context, it’s important to consider the differences between THC and CBD. Despite coming from the same plant, these cannabinoids behave very differently in the body and offer unique therapeutic effects.

Unlike THC, CBD does not have any psychoactive effects. This can be very helpful for patients who can’t tolerate the psychoactive side effects of THC.

CBD can also reduce symptoms of psychosis and anxiety, suggesting it may be a better alternative for Alzheimer’s patients suffering from psychiatric symptoms. THC, on the other hand, may exacerbate these symptoms.

CBD might improve memory deficits in Alzheimer’s disease. A 2014 studypublished in the journal Psychopharmacology found that CBD could reverse cognitive deficits in an animal model of Alzheimer’s when given on a regular basis.

In a 2017 study, CBD was found to reduce the levels of proteins that contribute to beta-amyloid plaque production.

CBD may also help promote growth of new brain cells that have died off because of beta-amyloid plaques. A 2011 study found that CBD increased neurogenesis in the hippocampus, an area that regulates memory and is damaged in Alzheimer’s disease.

In a 2017 review of the pre-clinical evidence for CBD as a treatment for Alzheimer’s, researchers found that CBD had anti-inflammatory and neuroprotective effects. However, these effects still require confirmation from clinical trials to determine whether the results are relevant to humans.

Summary

While preliminary research is promising, human trials are needed to determine if marijuana can be an effective treatment for Alzheimer’s disease.

Both THC and CBD have shown potential to reduce inflammation and protect neurons from damage by beta-amyloid plaques. In addition, CBD may promote the growth of new brain cells, and has fewer side effects than THC.

While there is not a lot of human research, some studies have found that THC can reduce behavioural disturbances in Alzheimer’s patients.

Based on early findings, some scientists believe marijuana has the potential to treat Alzheimer’s disease.

Source : Leaf Science